No, car motors are much heavier for the BHP output. Most bike motors rev higher than cage motors, so the gearing would be wrong. Plus, the added load., a 2200 # body would be a lot more load than the 400# or so of the bike.
If you did get the bike motor geared right, it would constantly rev higher and wear out faster. Many are air cooled, too, the lack of cooling air under hood would prove disastrous., Have to run a constant fan on them. The small savings in weight on that 2200# cage would be almost insignificant. My CB650 produces No Power below 2 grand, so, you'd be hitting the gas all the time just to get going from a red light. Not simply slipping the clutch from idle, like they are designed for. Hard on the clutch.
Engineers aren't stupid. A motorcycle's VeeTwin was used on the Morgan 3 wheeler, but, if you note, not tried Since. There is a Good reason.