Biochem/ free energy question?

Explain how a metabolic pathway (i.e. a series of connected reactions) can proceed when a given enzymatic reaction in the sequence has a positive free energy change?

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  • 1 month ago

    A reaction with a positive Delta G can be coupled through a common intermediate to a subsequent step with a negative Delta G. In this way, the spontaneous one can "pull" the non-spontaneous one in the forward direction.

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